CARs and cancers: questions and answers

被引:7
作者
Brentjens, Renier J. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
关键词
T-CELLS; PERSISTENCE; LYMPHOMA;
D O I
10.1182/blood-2012-02-410373
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:3872 / 3873
页数:2
相关论文
共 10 条
[1]
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias [J].
Brentjens, Renier J. ;
Riviere, Isabelle ;
Park, Jae H. ;
Davila, Marco L. ;
Wang, Xiuyan ;
Stefanski, Jolanta ;
Taylor, Clare ;
Yeh, Raymond ;
Bartido, Shirley ;
Borquez-Ojeda, Oriana ;
Olszewska, Malgorzata ;
Bernal, Yvette ;
Pegram, Hollie ;
Przybylowski, Mark ;
Hollyman, Daniel ;
Usachenko, Yelena ;
Pirraglia, Domenick ;
Hosey, James ;
Santos, Elmer ;
Halton, Elizabeth ;
Maslak, Peter ;
Scheinberg, David ;
Jurcic, Joseph ;
Heaney, Mark ;
Heller, Glenn ;
Frattini, Mark ;
Sadelain, Michel .
BLOOD, 2011, 118 (18) :4817-4828
[2]
Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens [J].
Dudley, Mark E. ;
Yang, James C. ;
Sherry, Richard ;
Hughes, Marybeth S. ;
Royal, Richard ;
Kammula, Udai ;
Robbins, Paul F. ;
Huang, JianPing ;
Citrin, Deborah E. ;
Leitman, Susan F. ;
Wunderlich, John ;
Restifo, Nicholas P. ;
Thomasian, Armen ;
Downey, Stephanie G. ;
Smith, Franz O. ;
Klapper, Jacob ;
Morton, Kathleen ;
Laurencot, Carolyn ;
White, Donald E. ;
Rosenberg, Steven A. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (32) :5233-5239
[3]
T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia [J].
Kalos, Michael ;
Levine, Bruce L. ;
Porter, David L. ;
Katz, Sharyn ;
Grupp, Stephan A. ;
Bagg, Adam ;
June, Carl H. .
SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (95)
[4]
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells [J].
Kochenderfer, James N. ;
Dudley, Mark E. ;
Feldman, Steven A. ;
Wilson, Wyndham H. ;
Spaner, David E. ;
Maric, Irina ;
Stetler-Stevenson, Maryalice ;
Phan, Giao Q. ;
Hughes, Marybeth S. ;
Sherry, Richard M. ;
Yang, James C. ;
Kammula, Udai S. ;
Devillier, Laura ;
Carpenter, Robert ;
Nathan, Debbie-Ann N. ;
Morgan, Richard A. ;
Laurencot, Carolyn ;
Rosenberg, Steven A. .
BLOOD, 2012, 119 (12) :2709-2720
[5]
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19 [J].
Kochenderfer, James N. ;
Wilson, Wyndham H. ;
Janik, John E. ;
Dudley, Mark E. ;
Stetler-Stevenson, Maryalice ;
Feldman, Steven A. ;
Maric, Irina ;
Raffeld, Mark ;
Nathan, Debbie-Ann N. ;
Lanier, Brock J. ;
Morgan, Richard A. ;
Rosenberg, Steven A. .
BLOOD, 2010, 116 (20) :4099-4102
[6]
CARs on Track in the Clinic [J].
Kohn, Donald B. ;
Dotti, Gianpietro ;
Brentjens, Renier ;
Savoldo, Barbara ;
Jensen, Michael ;
Cooper, Laurence J. N. ;
June, Carl H. ;
Rosenberg, Steven ;
Sadelain, Michel ;
Heslop, Helen E. .
MOLECULAR THERAPY, 2011, 19 (03) :432-438
[7]
Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2 [J].
Morgan, Richard A. ;
Yang, James C. ;
Kitano, Mio ;
Dudley, Mark E. ;
Laurencot, Carolyn M. ;
Rosenberg, Steven A. .
MOLECULAR THERAPY, 2010, 18 (04) :843-851
[8]
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients [J].
Savoldo, Barbara ;
Ramos, Carlos Almeida ;
Liu, Enli ;
Mims, Martha P. ;
Keating, Michael J. ;
Carrum, George ;
Kamble, Rammurti T. ;
Bollard, Catherine M. ;
Gee, Adrian P. ;
Mei, Zhuyong ;
Liu, Hao ;
Grilley, Bambi ;
Rooney, Cliona M. ;
Heslop, Helen E. ;
Brenner, Malcolm K. ;
Dotti, Gianpietro .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (05) :1822-1826
[9]
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells [J].
Till, Brian G. ;
Jensen, Michael C. ;
Wang, Jinjuan ;
Chen, Eric Y. ;
Wood, Brent L. ;
Greisman, Harvey A. ;
Qian, Xiaojun ;
James, Scott E. ;
Raubitschek, Andrew ;
Forman, Stephen J. ;
Gopal, Ajay K. ;
Pagel, John M. ;
Lindgren, Catherine G. ;
Greenberg, Philip D. ;
Riddell, Stanley R. ;
Press, Oliver W. .
BLOOD, 2008, 112 (06) :2261-2271
[10]
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results [J].
Till, Brian G. ;
Jensen, Michael C. ;
Wang, Jinjuan ;
Qian, Xiaojun ;
Gopal, Ajay K. ;
Maloney, David G. ;
Lindgren, Catherine G. ;
Lin, Yukang ;
Pagel, John M. ;
Budde, Lihua E. ;
Raubitschek, Andrew ;
Forman, Stephen J. ;
Greenberg, Philip D. ;
Riddell, Stanley R. ;
Press, Oliver W. .
BLOOD, 2012, 119 (17) :3940-3950