Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging

被引：255

作者：

Feng, B. ^{[1
,2
]}

Hong, R. Y. ^{[1
,2
,3
]}

Wang, L. S. ^{[1
,2
]}

Guo, L. ^{[4
]}

Li, H. Z. ^{[3
]}

Ding, J. ^{[5
]}

Zheng, Y. ^{[6
]}

Wei, D. G. ^{[7
]}

机构：

[1] Soochow Univ, Dept Chem Engn, SIP, Suzhou 215123, Peoples R China

[2] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, SIP, Suzhou 215123, Peoples R China

[3] Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase React, Beijing 100080, Peoples R China

[4] Soochow Univ, Affiliated Hosp 1, MRI Div, Suzhou 215007, Peoples R China

[5] IBM Corp, Rochester, MN 55901 USA

[6] Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada

[7] Harvard Univ, Sch Engn & Appl Sci, Ctr Nanoscale Syst, Cambridge, MA 02139 USA

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2008年 / 328卷 / 1-3期

基金：

中国国家自然科学基金;

关键词：

Magnetite nanoparticle (MNPs); PEG diacid; Magnetic fluids (MFs); Magnetic resonance imaging (MRI);

D O I：

10.1016/j.colsurfa.2008.06.024

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The magnetite (Fe3O4) nanoparticles (MNPs) coated with PEG diacid via covalent bonds were prepared for magnetic resonance imaging (MRI). The surface of MNPs was first coated with (3-aminopropyl) tri-ethoxysilane (APITES) by a silanization reaction and then linked with PEG diacid via the reaction between -NH2 and -COOH to form well-dispersed surface functionalized biocompatible MNPs. The obtained nanoparticles were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetry (TG). The MNPs had an average size of 20 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. In addition, PEG-6000 diacid coated Fe3O4 nanoparticles were used to perform the MRI experiments on the living rabbits with VX2 malignant tumor, the results showed that these nanoparticles appear to be a promising vehicle for MR imaging. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：52 / 59

页数：8

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