The place of genetics in ageing research

被引：39

作者：

Barzilai, Nir ^{[1
]}

Guarente, Leonard ^{[2
]}

Kirkwood, Thomas B. L. ^{[3
]}

Partridge, Linda ^{[4
,5
,6
]}

Rando, Thomas A. ^{[7
,8
]}

Slagboom, P. Eline ^{[9
]}

机构：

[1] Albert Einstein Coll Med, New York, NY 10461 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[4] Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

[5] UCL, Inst Hlth Ageing, London WC1E 6BT, England

[6] UCL, Dept Genet Evolut & Enrichment, London WC1E 6BT, England

[7] Stanford Univ, Sch Med, Glenn Labs Biol Aging, Stanford, CA 94305 USA

[8] VA Palo Alto Hlth Care Syst, Ctr Tissue Regenerat Repair & Restorat CTR3, Palo Alto, CA 94304 USA

[9] Leiden Univ, Med Ctr, Sect Mol Epidemiol, Netherlands Consortium Hlth Ageing, NL-2333 ZC Leiden, Netherlands

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 08期

关键词：

SMALL-MOLECULE ACTIVATORS; GENOME-WIDE ASSOCIATION; LIFE-SPAN EXTENSION; HUMAN LONGEVITY; SACCHAROMYCES-CEREVISIAE; SIBLINGS; AGE; REJUVENATION; MORTALITY; DECLINE;

D O I：

10.1038/nrg3290

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Rapidly increasing numbers of older people present many countries with growing social and economic challenges. Yet despite the far-reaching implications of ageing, its biological basis remains a topic of much debate. Recent advances in genomics have spurred research on ageing and lifespan in human populations, adding to extensive genetic studies being carried out in model organisms. But how far is ageing controlled by our genes? In this Viewpoint, six experts present their opinions and comment on future directions in ageing research.

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收藏

页码：589 / 594

页数：6

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