Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

被引：109

作者：

Beekman, Marian ^{[1
]}

Nederstigt, Christa ^{[1
]}

Suchiman, H. Eka D. ^{[1
]}

Kremer, Dennis ^{[1
]}

van der Breggen, Ruud ^{[1
]}

Lakenberg, Nico ^{[1
]}

Alemayehu, Wendimagegn Ghidey ^{[1
]}

de Craen, Anton J. M. ^{[1
]}

Westendorp, Rudi G. J. ^{[1
]}

Boomsma, Dorret I. ^{[2
]}

de Geus, Eco J. C. ^{[2
]}

Houwing-Duistermaat, Jeanine J. ^{[1
]}

Heijmans, Bastiaan T. ^{[1
]}

Slagboom, P. Eline ^{[1
,3
]}

机构：

[1] Leiden Univ, Med Ctr, NL-2300 RC Leiden, Netherlands

[2] Vrije Univ Amsterdam, NL-1081 BT Amsterdam, Netherlands

[3] Netherlands Consortium Healthy Ageing, NL-2300 RC Leiden, Netherlands

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 42期

关键词：

association; aging SNP; MAJOR DEPRESSIVE DISORDER; COMMON GENETIC-VARIANTS; PROSTATE-CANCER RISK; BREAST-CANCER; LEIDEN LONGEVITY; LOGIC REGRESSION; MORTALITY; CENTENARIANS; PREDICTION; SIBLINGS;

D O I：

10.1073/pnas.1003540107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.

引用

页码：18046 / 18049

页数：4

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