θ, a novel γ-aminobutyric acid type A receptor subunit

被引：260

作者：

Bonnert, TP ^{[1
]}

McKernan, RM ^{[1
]}

Farrar, S ^{[1
]}

le Bourdellès, B ^{[1
]}

Heavens, RP ^{[1
]}

Smith, DW ^{[1
]}

Hewson, L ^{[1
]}

Rigby, MR ^{[1
]}

Sirinathsinghji, DJS ^{[1
]}

Brown, N ^{[1
]}

Wafford, KA ^{[1
]}

Whiting, PJ ^{[1
]}

机构：

[1] Merck Sharp & Dohme Ltd, Res Labs, Ctr Res Neurosci, Harlow CM20 2QR, Essex, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 17期

关键词：

D O I：

10.1073/pnas.96.17.9891

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

gamma-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of subtypes with distinct temporal and spatial patterns of expression and distinct properties that presumably underlie a precise role for each subtype, The newest member of this gene family is the theta subunit. The deduced polypeptide sequence is 627 amino acids long and has highest sequence identity (50.5%) with the pi subunit. Within the rat striatum, this subunit coassembles with alpha 2, pi, and yl, suggesting that gamma-aminobutyric acid type A receptors consisting of arrangements other than ap + gamma, delta, or epsilon do exist. Expression of alpha 2 beta 1 gamma 1 theta in transfected mammalian cells leads to the formation of receptors with a 4-fold decrease in the affinity for gamma-aminobutyric acid compared with alpha 2 beta 1 gamma 1. This subunit has a unique distribution, with studies so far suggesting significant expression within monoaminergic neurons of both human and monkey brain.

引用

页码：9891 / 9896

页数：6

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