The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice

被引：36

作者：

Bellaire, BH

Elzer, PH

Baldwin, CL

Roop, RM

机构：

[1] Louisiana State Univ, Med Ctr, Dept Microbiol & Immunol, Shreveport, LA 71130 USA

[2] Louisiana State Univ, Dept Vet Sci, Ctr Agr, Baton Rouge, LA 70803 USA

[3] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 05期

关键词：

D O I：

10.1128/IAI.67.5.2615-2618.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella, and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant (Delta entC) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.

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页码：2615 / 2618

页数：4

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