The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes

被引：77

作者：

Elzer, PH ^{[1
]}

Phillips, RW ^{[1
]}

Robertson, GT ^{[1
]}

Roop, RM ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV, MED CTR, DEPT MICROBIOL & IMMUNOL, SHREVEPORT, LA 71130 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 11期

关键词：

D O I：

10.1128/IAI.64.11.4838-4841.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing bg cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions of the htrA gene product to the pathogenesis of B. abortus infections.

引用

页码：4838 / 4841

页数：4

共 30 条

[1] ARAYA LN, 1989, J IMMUNOL, V143, P3330
[2] BALDWIN CL, 1994, MACROPHAGE PATHOGEN, P363
[3] BAUMLER AJ, 1994, INFECT IMMUN, V62, P1623
[4] Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA
Boucher, JC
MartinezSalazar, J
Schurr, MJ
Mudd, MH
Yu, H
Deretic, V
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (02) : 511 - 523
[5] CLONING, EXPRESSION, AND OCCURRENCE OF THE BRUCELLA CU-ZN SUPEROXIDE-DISMUTASE
BRICKER, BJ
TABATABAI, LB
JUDGE, BA
DEYOE, BL
MAYFIELD, JE
[J]. INFECTION AND IMMUNITY, 1990, 58 (09) : 2935 - 2939
[6] CANNING PC, 1990, ADVANCES IN BRUCELLOSIS RESEARCH, P151
[7] POSITIVE CONTROL OF A REGULON FOR DEFENSES AGAINST OXIDATIVE STRESS AND SOME HEAT-SHOCK PROTEINS IN SALMONELLA-TYPHIMURIUM
CHRISTMAN, MF
MORGAN, RW
JACOBSON, FS
AMES, BN
[J]. CELL, 1985, 41 (03) : 753 - 762
[8] DEGRADATION OF OXIDATIVELY DENATURED PROTEINS IN ESCHERICHIA-COLI
DAVIES, KJA
LIN, SW
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1988, 5 (04) : 215 - 223
[9] OXIDATIVELY DENATURED PROTEINS ARE DEGRADED BY AN ATP-INDEPENDENT PROTEOLYTIC PATHWAY IN ESCHERICHIA-COLI
DAVIES, KJA
LIN, SW
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1988, 5 (04) : 225 - 236
[10] CHARACTERIZATION AND GENETIC COMPLEMENTATION OF A BRUCELLA-ABORTUS HIGH-TEMPERATURE-REQUIREMENT-A (HTRA) DELETION MUTANT
ELZER, PH
PHILLIPS, RW
KOVACH, ME
PETERSON, KM
ROOP, RM
[J]. INFECTION AND IMMUNITY, 1994, 62 (10) : 4135 - 4139

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