The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes

被引：77

作者：

Elzer, PH ^{[1
]}

Phillips, RW ^{[1
]}

Robertson, GT ^{[1
]}

Roop, RM ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV, MED CTR, DEPT MICROBIOL & IMMUNOL, SHREVEPORT, LA 71130 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 11期

关键词：

D O I：

10.1128/IAI.64.11.4838-4841.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing bg cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions of the htrA gene product to the pathogenesis of B. abortus infections.

引用

页码：4838 / 4841

页数：4

共 30 条

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