Atropisomeric amides:: stereoselective enolate chemistry and enantioselective synthesis via a new SmI2-mediated reduction

被引：105

作者：

Hughes, AD ^{[1
]}

Price, DA ^{[1
]}

Simpkins, NS ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 10期

关键词：

D O I：

10.1039/a901154d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of certain types of atropisomeric amides, incorporating an N-MEM-ortho-tert-butylaniline group, for stereoselective reactions, has been explored. Enolate reactions of these systems are highly diastereocontrolled, and enantiomerically enriched starting materials can be obtained, starting from lactic acid, via a new SmI2 mediated reduction process.

引用

页码：1295 / 1304

页数：10

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