Molecular signatures of natural selection

被引：1157

作者：

Nielsen, R ^{[1
]}

机构：

[1] Univ Copenhagen, Ctr Bioinformat, DK-2100 Copenhagen O, Denmark

[2] Univ Copenhagen, Dept Evolutionary Biol, DK-2100 Copenhagen O, Denmark

来源：

ANNUAL REVIEW OF GENETICS | 2005年 / 39卷

关键词：

Darwinian selection; neutrality tests; genome scans; positive selection; phylogenetic footprinting;

D O I：

10.1146/annurev.genet.39.073003.112420

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nomnathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.

引用

页码：197 / 218

页数：22

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