Renal K+ channels: Structure and function

被引：171

作者：

Wang, WH

Hebert, SC

Giebisch, G

机构：

[1] BRIGHAM & WOMENS HOSP, DEPT MED, DIV RENAL, LAB MOL PHYSIOL & BIOPHYS, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

[3] YALE UNIV, SCH MED, DEPT CELLULAR & MOL PHYSIOL, NEW HAVEN, CT 06520 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 1997年 / 59卷

关键词：

K channel; kidney; regulation; potassium secretion; volume regulation;

D O I：

10.1146/annurev.physiol.59.1.413

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The activity of potassium (K+) channels is intimately linked to several important transport functions in renal tubules. We review recent progress concerning the properties, site along the nephron, and physiological regulation of native K+ channels, and compare their characteristics with those of recently cloned K+ channels. We do not fully cover work on K+ channels in amphibian tubules, cell cultures, and single tubule cells and do not review K+ channels in mesangial cells.

引用

页码：413 / 436

页数：24

共 140 条

[31]

GOGELEIN H, 1990, RENAL PHYSIOL BIOCH, V13, P8

[32]

GOGELEIN H, 1987, PFLUGERS ARCH, V410, P424

[33] ROLE OF H5 DOMAIN IN DETERMINING PORE DIAMETER AND ION PERMEATION THROUGH CYCLIC NUCLEOTIDE-GATED CHANNELS [J].