Two-photon polymerization/micromolding of microscale barbs for medical applications

被引：4

作者：

Boehm, R. D. ^{[1
,2
]}

Chen, B. ^{[1
,2
]}

Gittard, S. D. ^{[1
,2
]}

Chichkov, B. N. ^{[1
,2
,3
]}

Monteiro-Riviere, N. A. ^{[1
,2
,4
]}

Nasir, A. ^{[5
,6
]}

Narayan, R. J. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27599 USA

[2] N Carolina State Univ, Chapel Hill, NC 27599 USA

[3] Laser Zentrum Hannover eV, D-30419 Hannover, Germany

[4] N Carolina State Univ, Ctr Chem Toxicol Res & Pharmacokinet, Dept Clin Sci, Raleigh, NC 27695 USA

[5] Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA

[6] Wake Res Associates, Raleigh, NC 27612 USA

来源：

JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY | 2014年 / 28卷 / 3-4期

基金：

美国国家科学基金会;

关键词：

tissue barb; wound sealant; two-photon polymerization; micromolding; indirect rapid prototyping; ADHESION; WIRE;

D O I：

10.1080/01694243.2012.693828

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Tissue barbs are small-scale structures that may be used for sutureless joining of tissues. In this study, several types of tissue barbs were fabricated using two-photon polymerization/micromolding, including two-pronged tissue barbs, eight-pronged tissue barbs, 10-pronged tissue barbs, and 16-pronged tissue barbs. Tissue barb penetration in porcine tissue was observed using confocal laser scanning microscopy. Constructs containing medical tape and tissue barbs were created by applying tissue barbs in a parallel arrangement to Transpore medical tape. These results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants.

引用

页码：387 / 398

页数：12

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