Investigation of the aerodynamic characteristics of inhaler aerosols with an inhalation simulation machine

被引：4

作者：

Lee, KC

Suen, KO

Yianneskis, M

Marriott, C

机构：

[1] UNIV LONDON KINGS COLL, DEPT MECH ENGN, CTR HEAT TRANSFER & FLUID FLOW MEASUREMENT, LONDON WC2R 2LS, ENGLAND

[2] UCL, DEPT ENGN MECH, LONDON WC2, ENGLAND

[3] UNIV LONDON KINGS COLL, DEPT PHARM, LONDON SW3 6LX, ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 130卷 / 01期

关键词：

dry powder inhaler; aerosol characteristics; turbulence; inhalation simulation;

D O I：

10.1016/0378-5173(95)04363-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An experimental facility comprising of an inhalation simulation machine and a laser-Doppler anemometer has been developed to investigate the aerodynamic characteristics of inhaler aerosols. The machine has been used to simulate transient inhalation flows with different degrees of inspiratory effort. Measurements of the mean flow and of the turbulence levels and time scales have been obtained for three commercially-available dry powder inhalers at different inhalation pressures. The results provide an extensive characterisation of aerosol aerodynamics and can aid the assessment of inhalers under various inhalation conditions.

引用

页码：103 / 113

页数：11

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