The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways

被引：19

作者：

Benayoun, Berenice A. ^{[2
,3
,4
,5
]}

Auer, Jana ^{[2
,3
]}

Caburet, Sandrine ^{[2
,3
,4
]}

Veitia, Reiner A. ^{[1
,2
,3
,4
]}

机构：

[1] Inst Cochin Genet Mol, Fac Med Cochin Port Royal, Equipe 21, INSERM U567,Team 21,Genet & Dev Dept, F-75014 Paris, France

[2] Inst Cochin Genet Mol, CNRS, UMR 8104, F-75014 Paris, France

[3] Univ Paris 05, Fac Med Cochin Port Royal, Paris, France

[4] Univ Paris 07, Paris, France

[5] Ecole Normale Super, F-75231 Paris, France

来源：

PROTEOMICS | 2008年 / 8卷 / 15期

关键词：

BPES; FOXL2; ovary; post-translational modifications; transcription factor;

D O I：

10.1002/pmic.200800084

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factor Forkhead box L subfamily member 2 (FOXL2) is involved in craniofacial development and ovarian function. Using 2-DE and immunoblotting, we show that it is highly modified post-translationally. The most outstanding feature of its migration profile is the presence of two distinct modification "trains" and the absence of intermediates. A theoretical analysis of the modification profile of FOXL2 suggests that it undergoes parallel processive/concerted modifications. The absence of intermediates is compatible with the recruitment of poorly modified FOXL2 into a post-translational "modification factory.".

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收藏

页码：3118 / 3123

页数：6

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