Long-range DNA contacts: romance in the nucleus?

被引：22

作者：

de Laat, Wouter ^{[1
]}

机构：

[1] Erasmus MC, Dept Cell Biol, NL-3015 GE Rotterdam, Netherlands

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 03期

关键词：

RNA-POLYMERASE-II; CHROMOSOME CONFORMATION; X-INACTIVATION; TRANSCRIPTION; CELLS; COLOCALIZATION; ASSOCIATIONS; ORGANIZATION; GENOME; GENES;

D O I：

10.1016/j.ceb.2007.04.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies show that genes far apart on the same chromosome or even on different chromosomes can come together in the nuclear space. It has been hypothesized that functionally related genes 'kiss' at transcription factories to coordinate their expression. Novel high-throughput methods, such as 4C technology, that study DNA interactions in an unbiased manner should uncover the generality of this romantic concept of nuclear architecture.

引用

页码：317 / 320

页数：4

共 20 条

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