Chemodosimetric Hg2+-selective signaling by mercuration of dichlorofluorescein derivatives

被引:94
作者
Choi, Myung Gil [1 ]
Ryu, De Hun [1 ]
Jeon, Hye Lim [1 ]
Cha, Sunyoung [1 ]
Cho, Janggeun [1 ]
Joo, Hyun Hye [1 ]
Hong, Kwan Soo [2 ]
Lee, Chulhyun [2 ]
Ahn, Sangdoo [1 ]
Chang, Suk-Kyu [1 ]
机构
[1] Chung Ang Univ, Dept Chem, Seoul 156756, South Korea
[2] Korea Basic Sci Inst, MRI Team, Cheongwon 363883, Chungbuk, South Korea
关键词
D O I
10.1021/ol8013446
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The chemodosimetric behavior of dichlorofluorescein derivatives toward Hg(2+) ions was investigated. Simple chemodosimetric systems showed selective and efficient signaling behaviors toward micromolar concentrations of Hg(2+) ions over other common interfering metal ions in an aqueous environment. The signaling mechanism is selective mercuration of the 4',5'-position of the xanthene moiety, which results in efficient chromogenic and fluorogenic signaling of Hg(2+)- ions in aqueous environment.
引用
收藏
页码:3717 / 3720
页数:4
相关论文
共 42 条
[1]   New biarsenical Ligands and tetracysteine motifs for protein labeling in vitro and in vivo: Synthesis and biological applications [J].
Adams, SR ;
Campbell, RE ;
Gross, LA ;
Martin, BR ;
Walkup, GK ;
Yao, Y ;
Llopis, J ;
Tsien, RY .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (21) :6063-6076
[2]   Ecological effects, transport, and fate of mercury: a general review [J].
Boening, DW .
CHEMOSPHERE, 2000, 40 (12) :1335-1351
[3]   A general strategy to convert the MerR family proteins into highly sensitive and selective fluorescent biosensors for metal ions [J].
Chen, P ;
He, CA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (03) :728-729
[4]   Fluorimetric optode membrane for sulfide detection [J].
Choi, MMF .
ANALYST, 1998, 123 (07) :1631-1634
[5]   Signal ratio amplification via modulation of resonance energy transfer: Proof of principle in an emission ratiometric Hg(II) sensor [J].
Coskun, Ali ;
Akkaya, Engin U. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (45) :14474-14475
[6]   Signaling recognition events with fluorescent sensors and switches [J].
de Silva, AP ;
Gunaratne, HQN ;
Gunnlaugsson, T ;
Huxley, AJM ;
McCoy, CP ;
Rademacher, JT ;
Rice, TE .
CHEMICAL REVIEWS, 1997, 97 (05) :1515-1566
[7]  
Desvergne J.-P., 1997, CHEMOSENSORS ION MOL
[8]   A long-wavelength fluorescent chemodosimeter selective for Cu(II) ion in water [J].
Dujols, V ;
Ford, F ;
Czarnik, AW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (31) :7386-7387
[9]   Concatenation of two molecular switches via a Fe(II)/Fe(III) couple [J].
Guo, XF ;
Zhang, DQ ;
Tao, HR ;
Zhu, DB .
ORGANIC LETTERS, 2004, 6 (15) :2491-2494
[10]   A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution [J].
Guo, XF ;
Qian, XH ;
Jia, LH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (08) :2272-2273