Signal ratio amplification via modulation of resonance energy transfer: Proof of principle in an emission ratiometric Hg(II) sensor

被引：388

作者：

Coskun, Ali ^{[1
]}

Akkaya, Engin U. ^{[1
]}

机构：

[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 45期

关键词：

BORADIAZAINDACENE EMISSION; BORON-DIPYRROMETHENE; LOGIC GATES; FLUORESCENT; FLUOROIONOPHORE; FLUOROPHORES; INDICATORS; SWITCHES; DYE; PET;

D O I：

10.1021/ja066144g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Boradiazaindacene dyads designed as energy transfer casettes can be modified to signal cation concentrations ratiometrically. If the energy transfer efficiency is increased via changing spectral overlap on cation binding, an enhancement of emission signal ratios can be obtained. A larger range of ratios results in highly improved sensitivity to analyte concentrations. We demonstrate this approach in a de novo design of a novel and highly selective ratiometric chemosensor for Hg(II) ions. Copyright © 2006 American Chemical Society.

引用

页码：14474 / 14475

页数：2

共 22 条

[1] Geometrically precisely defined multinanometer expansion/contraction motions in a resorcin[4]arene cavitand based molecular switch [J].

Azov, VA ;

Schlegel, A ;

Diederich, F .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (29) :4635-4638

[2] A highly potassium-selective ratiometric fluorescent indicator based on BODIPY azacrown ether excitable with visible light [J].

Baruah, M ;

Qin, WW ;

Vallée, RAL ;

Beljonne, D ;

Rohand, T ;

Dehaen, W ;

Boens, N .

ORGANIC LETTERS, 2005, 7 (20) :4377-4380

[3] Synthesis and spectroscopic characterisation of BODIPY® based fluorescent off-on indicators with low affinity for calcium [J].

Basaric, N ;

Baruah, M ;

Qin, WW ;

Metten, B ;

Smet, M ;

Dehaen, W ;

Boens, N .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2005, 3 (15) :2755-2761

[4] Luminescent sensors and switches in the early 21st century [J].

Callan, JF ;

de Silva, AP ;

Magri, DC .

TETRAHEDRON, 2005, 61 (36) :8551-8588

[5] Effective PET and ICT switching of boradiazaindacene emission: A unimolecular, emission-mode, molecular half-subtractor with reconfigurable logic gates [J].

Coskun, A ;

Deniz, E ;

Akkaya, EU .

ORGANIC LETTERS, 2005, 7 (23) :5187-5189

[6] Ion sensing coupled to resonance energy transfer: A highly selective and sensitive ratiometric fluorescent chemosensor for Ag(I) by a modular approach [J].

Coskun, A ;

Akkaya, EU .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (30) :10464-10465

[7] The development of molecular fluorescent switches [J].

de Silva, AP ;

Fox, DB ;

Moody, TS ;

Weir, SM .

TRENDS IN BIOTECHNOLOGY, 2001, 19 (01) :29-34

[8] Distyryl-boradiazaindacenes: facile synthesis of novel near IR emitting fluorophores [J].

Dost, Zeynep ;

Atilgan, Serdar ;

Akkaya, Engin U. .

TETRAHEDRON, 2006, 62 (36) :8484-8488

[9] Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe [J].

Gabe, Y ;

Urano, Y ;

Kikuchi, K ;

Kojima, H ;

Nagano, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (10) :3357-3367

[10]

GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440

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