共 58 条
SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages
被引:98
作者:

Chiu, Shang-Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA

Asai, Naoya
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya Univ, Dept Pathol, Nagoya, Aichi 4648601, Japan
Columbia Univ, Dept Genet & Dev, Med Ctr, New York, NY USA Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA

Costantini, Frank
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Genet & Dev, Med Ctr, New York, NY USA Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA

Hsu, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA
机构:
[1] Univ Rochester, Med Ctr, Ctr Oral Biol, James P Wilmot Canc Ctr,Dept Biomed Genet, Rochester, NY 14642 USA
[2] Nagoya Univ, Dept Pathol, Nagoya, Aichi 4648601, Japan
[3] Columbia Univ, Dept Genet & Dev, Med Ctr, New York, NY USA
来源:
基金:
美国国家卫生研究院;
关键词:
D O I:
10.1371/journal.pbio.0060310
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
SUMO-specific protease 2 (SENP2) modifies proteins by removing SUMO from its substrates. Although SUMO-specific proteases are known to reverse sumoylation in many defined systems, their importance in mammalian development and pathogenesis remains largely elusive. Here we report that SENP2 is highly expressed in trophoblast cells that are required for placentation. Targeted disruption of SENP2 in mice reveals its essential role in development of all three trophoblast layers. The mutation causes a deficiency in cell cycle progression. SENP2 has a specific role in the G-S transition, which is required for mitotic and endoreduplication cell cycles in trophoblast proliferation and differentiation, respectively. SENP2 ablation disturbs the p53-Mdm2 pathway, affecting the expansion of trophoblast progenitors and their maturation. Reintroducing SENP2 into the mutants can reduce the sumoylation of Mdm2, diminish the p53 level and promote trophoblast development. Furthermore, downregulation of p53 alleviates the SENP2-null phenotypes and stimulation of p53 causes abnormalities in trophoblast proliferation and differentiation, resembling those of the SENP2 mutants. Our data reveal a key genetic pathway, SENP2-Mdm2-p53, underlying trophoblast lineage development, suggesting its pivotal role in cell cycle progression of mitosis and endoreduplication.
引用
收藏
页码:2801 / 2816
页数:16
相关论文
共 58 条
[11]
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
[J].
Giroux, S
;
Tremblay, M
;
Bernard, D
;
Cadrin-Girard, JF
;
Aubry, S
;
Larouche, L
;
Rousseau, S
;
Huot, J
;
Landry, J
;
Jeannotte, L
;
Charron, J
.
CURRENT BIOLOGY,
1999, 9 (07)
:369-372

Giroux, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Tremblay, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Bernard, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Cadrin-Girard, JF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Aubry, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Larouche, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Rousseau, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Huot, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Landry, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Jeannotte, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

Charron, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada Univ Laval, CHU Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada
[12]
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
[J].
Gostissa, M
;
Hengstermann, A
;
Fogal, V
;
Sandy, P
;
Schwarz, SE
;
Scheffner, M
;
Del Sal, G
.
EMBO JOURNAL,
1999, 18 (22)
:6462-6471

Gostissa, M
论文数: 0 引用数: 0
h-index: 0
机构: Consorzio Interuniv Biotecnol, Lab Nazl, I-34012 Trieste, Italy

Hengstermann, A
论文数: 0 引用数: 0
h-index: 0
机构: Consorzio Interuniv Biotecnol, Lab Nazl, I-34012 Trieste, Italy

Fogal, V
论文数: 0 引用数: 0
h-index: 0
机构: Consorzio Interuniv Biotecnol, Lab Nazl, I-34012 Trieste, Italy

Sandy, P
论文数: 0 引用数: 0
h-index: 0
机构: Consorzio Interuniv Biotecnol, Lab Nazl, I-34012 Trieste, Italy

Schwarz, SE
论文数: 0 引用数: 0
h-index: 0
机构: Consorzio Interuniv Biotecnol, Lab Nazl, I-34012 Trieste, Italy

Scheffner, M
论文数: 0 引用数: 0
h-index: 0
机构: Consorzio Interuniv Biotecnol, Lab Nazl, I-34012 Trieste, Italy

论文数: 引用数:
h-index:
机构:
[13]
Essential role for ERK2 mitogen-activated protein kinase in placental development
[J].
Hatano, N
;
Mori, Y
;
Oh-Hora, M
;
Kosugi, A
;
Fujikawa, T
;
Nakai, N
;
Niwa, H
;
Miyazaki, J
;
Hamaoka, T
;
Ogata, M
.
GENES TO CELLS,
2003, 8 (11)
:847-856

Hatano, N
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Mori, Y
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Oh-Hora, M
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Kosugi, A
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Fujikawa, T
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Nakai, N
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Niwa, H
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Miyazaki, J
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Hamaoka, T
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan

Ogata, M
论文数: 0 引用数: 0
h-index: 0
机构: Mie Univ, Sch Med, Dept Biochem, Tsu, Mie 5148507, Japan
[14]
Mdm2 promotes the rapid degradation of p53
[J].
Haupt, Y
;
Maya, R
;
Kazaz, A
;
Oren, M
.
NATURE,
1997, 387 (6630)
:296-299

论文数: 引用数:
h-index:
机构:

Maya, R
论文数: 0 引用数: 0
h-index: 0
机构: WEIZMANN INST SCI,DEPT MOL CELL BIOL,IL-76100 REHOVOT,ISRAEL

Kazaz, A
论文数: 0 引用数: 0
h-index: 0
机构: WEIZMANN INST SCI,DEPT MOL CELL BIOL,IL-76100 REHOVOT,ISRAEL

Oren, M
论文数: 0 引用数: 0
h-index: 0
机构: WEIZMANN INST SCI,DEPT MOL CELL BIOL,IL-76100 REHOVOT,ISRAEL
[15]
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
[J].
Honda, R
;
Tanaka, H
;
Yasuda, H
.
FEBS LETTERS,
1997, 420 (01)
:25-27

Honda, R
论文数: 0 引用数: 0
h-index: 0
机构:
Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 19203, Japan Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 19203, Japan

Tanaka, H
论文数: 0 引用数: 0
h-index: 0
机构:
Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 19203, Japan Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 19203, Japan

Yasuda, H
论文数: 0 引用数: 0
h-index: 0
机构:
Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 19203, Japan Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 19203, Japan
[16]
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
[J].
Hsu, W
;
Shakya, R
;
Costantini, F
.
JOURNAL OF CELL BIOLOGY,
2001, 155 (06)
:1055-1064

Hsu, W
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

Shakya, R
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

Costantini, F
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
[17]
Identification of a domain of axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
[J].
Hsu, W
;
Zeng, L
;
Costantini, F
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (06)
:3439-3445

Hsu, W
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

Zeng, L
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

Costantini, F
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
[18]
Cathepsin gene expression in mouse placenta during the latter half of pregnancy
[J].
Ishida, M
;
Ono, K
;
Taguchi, S
;
Ohashi, S
;
Naito, J
;
Horiguchi, K
;
Harigaya, T
.
JOURNAL OF REPRODUCTION AND DEVELOPMENT,
2004, 50 (05)
:515-523

Ishida, M
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

Ono, K
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

Taguchi, S
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

Ohashi, S
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

Naito, J
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

Horiguchi, K
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

Harigaya, T
论文数: 0 引用数: 0
h-index: 0
机构:
Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan Meiji Univ, Fac Agr, Dept Life Sci, Funct Anat Lab,Tama Ku, Kawasaki, Kanagawa 2148571, Japan
[19]
Inhibition of Wnt signaling pathway by a novel axin-binding protein
[J].
Kadoya, T
;
Kishida, S
;
Fukui, A
;
Hinoi, T
;
Michiue, T
;
Asashima, M
;
Kikuchi, A
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2000, 275 (47)
:37030-37037

Kadoya, T
论文数: 0 引用数: 0
h-index: 0
机构: Hiroshima Univ, Sch Med, Dept Biochem, Minami Ku, Hiroshima 7348551, Japan

论文数: 引用数:
h-index:
机构:

Fukui, A
论文数: 0 引用数: 0
h-index: 0
机构: Hiroshima Univ, Sch Med, Dept Biochem, Minami Ku, Hiroshima 7348551, Japan

Hinoi, T
论文数: 0 引用数: 0
h-index: 0
机构: Hiroshima Univ, Sch Med, Dept Biochem, Minami Ku, Hiroshima 7348551, Japan

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:
[20]
Increase of the trophoblast giant cells with prolactin-releasing peptide (PrRP) receptor expression in p53-null mice
[J].
Komatsu, Daisuke
;
Abe, Takumi
;
Sano, Yoshihiro
;
Shimazaki, Kiyoe
;
Tomita, Motowo
;
Kanayama, Naohiro
;
Takahashi, Katsuhiko
.
MOLECULAR REPRODUCTION AND DEVELOPMENT,
2007, 74 (09)
:1089-1094

Komatsu, Daisuke
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan

Abe, Takumi
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan

Sano, Yoshihiro
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan

Shimazaki, Kiyoe
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan

Tomita, Motowo
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan

Kanayama, Naohiro
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan

Takahashi, Katsuhiko
论文数: 0 引用数: 0
h-index: 0
机构: Showa Univ, Sch Med, Dept Neurosurg, Shinagawa Ku, Tokyo 142, Japan