Dimeric aminoglycosides as antibiotics

被引：57

作者：

Agnelli, T

Sucheck, SJ

Marby, KA

Rabuka, D

Yao, SL

Sears, PS

Liang, FS

Wong, CH

机构：

[1] Optimer Pharmaceut Inc, San Diego, CA 92121 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 12期

关键词：

anninoglycosides; antibiotics; carbohydrates; drug design; RNA recognition;

D O I：

10.1002/anie.200353225

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double duty: Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition. The resulting dimeric aminoglycosides displayed high affinity for the 16S A site of ribosomal RNA (a representation of the complex is shown here) and were effective against various aminoglycoside-resistant bacterial strains.

引用

页码：1562 / 1566

页数：5

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