Design, modeling and synthesis of functionalized paromamine analogs

被引：34

作者：

Hanessian, S ^{[1
]}

Tremblay, M ^{[1
]}

Kornienko, A ^{[1
]}

Moitessier, N ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Quebec City, PQ H3C 3J7, Canada

来源：

TETRAHEDRON | 2001年 / 57卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

aminoglycoside; paromomycin; RNA; library; modeling;

D O I：

10.1016/S0040-4020(01)00194-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on the published NMR structure of the antibiotic paromomycin complexed with the A-site of Escherichia coli 16S ribosomal RNA, a set of C-5 functionalized analogs of paromamine was designed and synthesized, incorporating cyclic and acyclic appendages and terminating with one or more ammonium groups. (C) 2001 Elsevier Science Ltd. Ah rights reserved.

引用

页码：3255 / 3265

页数：11

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