A catalytic, Me2Zn-mediated, enantioselective reformatsky reaction with ketones

被引：68

作者：

Cozzi, Pier Giorgio ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 18期

关键词：

enantioselectivity; homogeneous catalysis; ketones; manganese; N ligands;

D O I：

10.1002/anie.200504239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Kill two birds with one ... Salen! A catalytic and practical Me2Zn-mediated enantioselective Reformatsky reaction promoted by [ClMn(salen)] with a ketone as the electrophile is presented (see scheme). The broad scope and simple nature of this procedure, which allows the use of commercially available starting materials and leads to useful building blocks containing quaternary stereocenters, make it extremely attractive. (salen = N,N′-ethylene-bis(salicylideneamine).). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2951 / 2954

页数：4

共 54 条

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