Heat Enhances Gas Delivery And Acoustic Attenuation in CO2 Filled Microbubbles

被引：6

作者：

Giustetto, Pierangela ^{[1
]}

Bisazza, Agnese ^{[2
]}

Biagioni, Angelo ^{[3
]}

Alippi, Adriano ^{[3
]}

Bettucci, Andrea ^{[3
]}

Cavalli, Roberta ^{[2
]}

Guiot, Caterina ^{[4
]}

机构：

[1] Univ Turin, Dept Neurosci, Turin, Italy

[2] Univ Turin, Dept Drug Sci & Technol, I-10124 Turin, Italy

[3] Univ Roma La Sapienza, Dept Acoust, I-00185 Rome, Italy

[4] Univ Turin, CCNISM, I-10124 Turin, Italy

来源：

2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8 | 2008年

关键词：

chitosan; microbubbles; US imaging; hyperthermia;

D O I：

10.1109/IEMBS.2008.4649659

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Thermo-responsive chitosan microbubbles were developed as new therapeutic device for vehiculating gases to tissues concomitantly to hyperthermic treatments. Aiming at applications to non-invasive temperature monitoring, microbubbles were characterized for acoustic attenuation properties in the 1-15 MHz range both by direct methods and by B-mode Ultrasound imaging up to 43 degrees C, which is the temperature used in clinical hyperthermia. The chitosan microbubbles showed a mean diameter of 1 mu m at room temperature, which slightly decreases after heating, enhancing gas delivery. Acoustic attenuation monotonically increases with temperature, being the extent of such variation larger than that observed in tissues. Both the physico-chemical and the acoustic profiles showed reversible variations of microbubbles approaching 43 degrees C, which might be of interest for applications in hyperthermic therapies.

引用

页码：2306 / +

页数：2

共 14 条

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