Inducible nitric oxide synthase activation by interleukin-17

被引：112

作者：

Miljkovic, D

Trajkovic, V

机构：

[1] Univ Belgrade, Inst Microbiol & Immunol, Sch Med, YU-11000 Belgrade, Serbia

[2] Inst Biol Res, Belgrade, Serbia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2004年 / 15卷 / 01期

关键词：

IL-17; nitric oxide; iNOS; autoimmunity;

D O I：

10.1016/j.cytogfr.2003.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-17 (IL-17) is a proinflammatory T cell cytokine presumably involved in physiological responses to infection, but also in immunopathology of autoimmune disorders such as rheumatoid arthritis. The proinflammatory action of IL-17 depends considerably on its ability to trigger the expression of inducible nitric oxide (NO) synthase (iNOS), an enzyme responsible for the generation of cytotoxic and immunoregulatory free radical NO. Here we discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze signaling pathways employed by IL-17 for the initiation of iNOS gene transcription. We also propose biological consequences of IL-17-mediated NO release that could be relevant for the mechanisms or therapy of autoimmune and inflammatory disorders. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：21 / 32

页数：12

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