Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

被引：130

作者：

Neugebauer, Ute ^{[1
]}

Pellegrin, Yann ^{[1
]}

Devocelle, Marc ^{[3
]}

Forster, Robert J. ^{[1
,2
]}

Signac, William

Morand, Niamh

Keyes, Tia E. ^{[1
,2
]}

机构：

[1] Dublin City Univ, Biomed Diagnost Inst, Dublin 9, Ireland

[2] Dublin City Univ, Sch Chem Sci, Natl Ctr Sensor Res, Dublin 9, Ireland

[3] Royal Coll Surgeons Ireland, Ctr Synth & Chem Biol, Dept Pharmaceut & Med Chem, Dublin 2, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 42期

基金：

爱尔兰科学基金会;

关键词：

D O I：

10.1039/b810403d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R-5), and one to eight arginine residues, (Ru-Ahx-R-8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence; (Ru-R-8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for its permeablisation.

引用

页码：5307 / 5309

页数：3

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