A comparative study of the interaction of two structurally analogue ruthenium(II) complexes with DNA

被引：39

作者：

Bai, GY

Dong, B

Lü, YY

Wang, KZ ^{[1
]}

Jin, LP

Gao, LH

机构：

[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

[2] Beijing Technol & Business Univ, Sch Chem & Environm Engn, Beijing 100037, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2004年 / 98卷 / 12期

关键词：

ruthenium complex; DNA; spectroscopy;

D O I：

10.1016/j.jinorgbio.2004.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The binding of the ruthenium(II) complexes of [Ru(bPY)(2)(CAIP)]Cl-2 and [Ru(bPY)(2)(HClP)]Cl-2 (where bpy = 2,2'-bipyridine, CAI P = 4-carboxyl-imidado [4,5-f][1, 10]-phenanthroline, HCIP=3-hydroxyl-4-carboxyl-imidado[4,5-f[1,10]-phenanthroline) to calf thymus DNA (ct-DNA) has been investigated with UV-visible and emission spectroscopy, steady-state emission quenching, and viscosity measurements. The experimental results indicate that the two complexes bind to ct-DNA through an intercalative mode and [Ru(bpy)2(HClp)](2+) intercalates into DNA more deeply than [Ru(bPY)2(CAI p)] 2+ does. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：2011 / 2015

页数：5

共 30 条

[1] [Ru(η6-p-cymene)Cl2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane):: a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells [J].