[Ru(η6-p-cymene)Cl2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane):: a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

被引：481

作者：

Allardyce, CS ^{[1
]}

Dyson, PJ ^{[1
]}

Ellis, DJ ^{[1
]}

Heath, SL ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 15期

关键词：

D O I：

10.1039/b104021a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The water soluble complex [Ru(eta (6)-p-cymene)Cl-2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane), exhibits pH dependent DNA damage; the pH at which damage is greatest correlates well to the pH environment of cancer cells.

引用

页码：1396 / 1397

页数：2

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