microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

被引：212

作者：

Leucci, Eleonora ^{[1
,2
]}

Patella, Francesca ^{[1
,2
,3
]}

Waage, Johannes ^{[1
,2
,4
]}

Holmstrom, Kim ^{[6
]}

Lindow, Morten ^{[7
]}

Porse, Bo ^{[1
,2
,4
,5
]}

Kauppinen, Sakari ^{[8
]}

Lund, Anders H. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Biotech Res & Innovat Ctr, DK-1168 Copenhagen, Denmark

[2] Univ Copenhagen, Ctr Epigenet, DK-1168 Copenhagen, Denmark

[3] Scuola Super Sant Anna, Pisa, Italy

[4] Univ Copenhagen, Fac Hlth Sci, Rigshosp, Finsen Lab, DK-1168 Copenhagen, Denmark

[5] Univ Copenhagen, Fac Hlth Sci, Danish Stem Cell Ctr DanStem, DK-1168 Copenhagen, Denmark

[6] Bioneer AS, Horsholm, Denmark

[7] Santaris Pharma, Horsholm, Denmark

[8] Aalborg Univ Hosp, Dept Haematol, Aalborg, Denmark

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

IN-VIVO; EVOLUTION; MIR-9;

D O I：

10.1038/srep02535

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.

引用

页数：6

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