Dendrimeric micelles for controlled drug release and targeted delivery

被引:213
作者
Ambade, Ashootosh V. [1 ]
Savariar, Elamprakash N. [1 ]
Thayumanavan, S. [1 ]
机构
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
基金
美国国家卫生研究院;
关键词
micelle; drug delivery; dendrimers; controlled release; targeted delivery; polymer-drug conjugates;
D O I
10.1021/mp050020d
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 [基础医学];
摘要
This review highlights the developments in dendrimer-based micelles for drug delivery. Dendrimers, the perfectly branched monodisperse macromolecules, have certain structural advantages that make them attractive candidates as drug carriers for controlled release or targeted delivery. As polymeric micelle-based approaches precede the work in dendrimers, these are also discussed briefly. The review concludes with a perspective on possible applications of biaryl-based dendrimeric micelles that exhibit environment-dependent conformations, in drug delivery.
引用
收藏
页码:264 / 272
页数:9
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