Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain

被引：40

作者：

Deniz-Naranjo, M. C. ^{[1
]}

Munoz-Fernandez, C. ^{[2
]}

Alemany-Rodriguez, M. J. ^{[2
]}

Perez-Vieitez, M. C. ^{[2
]}

Aladro-Benito, Y. ^{[2
]}

Irurita-Latasa, J. ^{[3
]}

Sanchez-Garcia, F. ^{[1
]}

机构：

[1] Hosp Univ Dr Negrin Gran Canaria, Dept Immunol, Las Palmas Gran Canaria 35010, Spain

[2] Hosp Univ Dr Negrin Gran Canaria, Dept Neurol, Las Palmas Gran Canaria 35010, Spain

[3] Hosp Univ Dr Negrin Gran Canaria, Dept Psychiat, Las Palmas Gran Canaria 35010, Spain

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2008年 / 15卷 / 10期

关键词：

Alzheimer disease; APOE4; Canary Islands; interleukin-1; alpha; beta; promoter polymorphisms; Spain;

D O I：

10.1111/j.1468-1331.2008.02252.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aims: Previous studies have reported the presence of low-grade inflammation in Alzheimer disease (AD). Based on these data, our work attempts to investigate the effects of some promoter polymorphisms of pro-inflammatory cytokines [interleukin (IL)-1 alpha and IL-1 beta] on AD. Patients and methods: A PCR-RFLP technique was used to analyze the promoter polymorphisms of both IL-1 alpha (-889 C/T) and IL-1 beta (-511 C/T) and the APOE genotype from the DNA samples of 282 patients (according to NINCDS-ADRDA criteria) and 312 control subjects. Results: (i) The risk of developing AD in our population was associated with the IL-1 beta (-511 C/T) promoter polymorphism; (ii) such risk was independent of the risk factor allele in the APOE gene (APOE4); and (iii) the IL-1 alpha promoter polymorphism (-889 C/T) was not associated with the disease. Conclusion: In our population, IL-1 beta promoter polymorphism (-511 C/T) is an independent risk factor for AD.

引用

页码：1080 / 1084

页数：5

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