Gender has a strong modulating effect on the risk of Alzheimer's disease conferred by the apolipoprotein E gene in the population of the Canary Islands, Spain

被引：1

作者：

Déniz-Naranjo, MC

Muñoz-Fernández, C

Alemany-Rodríguez, MJ

Pérez-Vléitez, MC

Aladro-Benito, Y

Irurita-Latasa, J

Suárez-Armas, R

Suárez-Valentín, MP

Sánchez-García, F

机构：

[1] Hosp Dr Negrin Gran Canaria, Serv Immunol, E-35020 Las Palmas Gran Canaria, Spain

[2] Hosp Dr Negrin Gran Canaria, Neurol Serv, E-35020 Las Palmas Gran Canaria, Spain

[3] Hosp Dr Negrin Gran Canaria, Serv Psiquiatria, E-35020 Las Palmas Gran Canaria, Spain

[4] Hosp Insular Gran Canaria, Serv Med Prevent, Las Palmas Gran Canaria, Spain

来源：

REVISTA DE NEUROLOGIA | 2004年 / 38卷 / 07期

关键词：

Alzheimer disease; Canary Islands; exonic ApoE polymorphisms; promoter ApoE polymorphisms; Spain;

D O I：

10.33588/rn.3807.2003264

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives. Apolipoprotein E (ApoE) gen has been found to confer risk for Alzheimer disease in every population studied. We are interested in analyzed the exonic variants and the promoter polymorphisms in our Canary population. Subjects and methods. By means of PCR-RFLP analysis of DNA from patients (NINCS-ADRDA criteria) and controls (cognitive state CAMCOG test measured) we analyzed the known exonic and promoter polymorphism of ApoE gen. Results. We have found an association of Alzheimer disease risk based on exonic variants of ApoE gen, with a clear cut dose-effect on susceptibility and no risk conferred by the promoter polymorphisms. Age at onset are not affected by variants of ApoE gen, and patients gender strongly modulate the disease susceptibility. Conclusion. We have found in our Canary population an association between Alzheimer disease with exonic variants of ApoE gen with a strong modulation by the patients gender.

引用

页码：615 / 618

页数：4

共 34 条

[1] APOLIPOPROTEIN E4 ALLELE FREQUENCY IN SPANISH ALZHEIMER AND CONTROL CASES [J].