Release Dynamics of Brufen from a Drug-Loaded Polymer Hydrogel Containing Polyvinyl Alcohol, 2-Acrylamide-2-methylpropane Sulfonic Acid and Acrylamide

A novel hydrogel composed of gelatin, sodium salt of 2-acrylamido-2-methyl propane sulfonic acid (Na-AMPS), and acryl amide (AM) was using N,N-methylenebisacrylamide (MBA) as crosslinker and Potassium peroxodisulfate (KPS) as initiator in aqueous medium. The influence of various parameters on the equilibrium swelling ratio of the hydrogel were investigated. The drug release kinetics of the hydrogel loaded with tetracycline (TC) was studied at 370. The results obtained during experimental analysis showed that molar amount in cross linking agent as well as the monomers greatly affected the swelling ratio of the hydrogel and release kinetics of the model drug. The equilibrium release percent of TC reached about 80% release after 96 hours and the fractional release rate was controlled by the swelling of the hydrogel.