Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia

被引：51

作者：

Pedersen, Anya ^{[1
]}

Diedrich, Markus ^{[1
]}

Kaestner, Florian ^{[1
]}

Koelkebeck, Katja ^{[1
]}

Ohrmann, Patricia ^{[1
]}

Ponath, Gerald ^{[1
]}

Kipp, Frank ^{[2
]}

Abel, Simone ^{[1
]}

Siegmund, Ansgar ^{[1
]}

Suslow, Thomas ^{[1
]}

von Eiff, Christof ^{[2
]}

Arolt, Volker ^{[1
]}

Rothermundt, Matthias ^{[1
]}

机构：

[1] Univ Med Fac, Dept Psychiat, D-48149 Munster, Germany

[2] Univ Med Fac, Inst Med Microbiol, D-49149 Munster, Germany

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2008年 / 32卷 / 08期

关键词：

Astrocytes; Memory; S100; B; Schizophrenia;

D O I：

10.1016/j.pnpbp.2008.07.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Astrocyte activation indicated by increased S100B is considered a potential pathogenic factor for schizophrenia. To investigate the relationship between astrocyte activation and cognitive performance, S100B serum concentration, memory performance, and psychopathology were assessed in 40 first-episode and 35 chronic schizophrenia patients upon admission and after four weeks of treatment. Chronic schizophrenia patients with high S100B were impaired concerning verbal memory performance (AVLT, Auditory Verbal Learning Test) compared to chronic and first-episode patients with low S100B levels. The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1789 / 1792

页数：4

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