Nutritional programming of insulin resistance: causes and consequences

被引：119

作者：

Duque-Guimaraes, Danielle E.

Ozanne, Susan E. ^{[1
]}

机构：

[1] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 10期

基金：

英国医学研究理事会;

关键词：

nutritional programming; insulin resistance; epigenetics; metabolic diseases; LOW-BIRTH-WEIGHT; HIGH-FAT DIET; SIGNALING PROTEIN EXPRESSION; THRIFTY PHENOTYPE HYPOTHESIS; LONG-TERM CONSEQUENCES; METABOLIC SYNDROME; GLUCOSE-METABOLISM; MATERNAL OBESITY; GENE-EXPRESSION; ADIPOSE-TISSUE;

D O I：

10.1016/j.tem.2013.05.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Strong evidence indicates that adverse prenatal and early postnatal environments have a significant long-term influence on risk factors that result in insulin resistance, type 2 diabetes (T2D), and cardiovascular disease later in life. Here we discuss current knowledge of how maternal and neonatal nutrition influence early growth and the long-term risk of developing insulin resistance in different organs and at the whole-body level. Accumulating evidence supports a role for epigenetic mechanisms underlying this nutritional programming, consisting of heritable changes that regulate gene expression which in turn shapes the phenotype across generations. Deciphering these molecular mechanisms in key tissues and discovering key biological markers may provide valuable insight towards the development of effective intervention strategies.

引用

页码：525 / 535

页数：11

共 143 条

[1]

A systematic review on animal models of maternal high fat feeding and offspring glycaemic control [J].