Fluoroform-Derived CuCF3 for Low-Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air

被引：206

作者：

Novak, Petr ^{[1
]}

Lishchynskyi, Anton ^{[1
]}

Grushin, Vladimir V. ^{[1
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 31期

关键词：

arenes; aryl boronic acids; copper; fluorine; trifluoromethylation; OXIDATIVE TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; ESTERS; REAGENT; PERFLUOROALKYL; ARENES; SUZUKI;

D O I：

10.1002/anie.201201613

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low-cost fluoroform-derived CuCF 3 in DMF in non-dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented functional-group tolerance, and affords trifluoromethylated aromatic compounds in up to 99 % yield. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7767 / 7770

页数：4

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