Copper-Mediated Oxidative Trifluoromethylation of Boronic Acids

被引：330

作者：

Chu, Lingling ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 21期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; ARYLBORONIC ACIDS; BOND FORMATION; REDUCTIVE ELIMINATION; CATALYZED SYNTHESIS; CONVENIENT METHOD; HIGHLY EFFICIENT; ORGANIC HALIDES; FLUORINE; ARENES;

D O I：

10.1021/ol1023135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-mediated oxidative cross-coupling of aryl- and alkenylboronic acids with (trifluoromethyl)trimethylsilane (Me3SiCF3) under mild conditions has been developed. This method allows a wide range of functional group tolerant trifluoromethylated arenes and alkenes to be easily prepared. This oxidative trifluoromethylation has the potential to introduce trifluoromethyl groups into advanced, highly functionalized organic molecules.

引用

收藏

页码：5060 / 5063

页数：4

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