Aryl-CF3 Bond-Forming Reductive Elimination from Palladium(IV)

被引：255

作者：

Ball, Nicholas D. ^{[1
]}

Kampf, Jeff W. ^{[1
]}

Sanford, Melanie S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 09期

关键词：

TRIFLUOROMETHYLATION REACTIONS; SODIUM TRIFLUOROACETATE; CONVENIENT METHOD; C-O; COMPLEXES; FLUORINATION; REACTIVITY; HALIDES; IODIDE; ACTIVATION;

D O I：

10.1021/ja100955x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication describes oxidatively induced Ar-CF3 bond-forming reductive elimination from new Pd-II complexes of general structure (L similar to L)Pd-II(Ar)(CF3). The electrophilic fluorinating reagent N-fluoro-2,4,6-trimethylpyridinium triflate promotes these reactions in good to excellent yields. The palladium (IV) intermediate ('Bu-bpy)Pd-IV(CF3)(F)(OTf)(C6H4F) has been isolated, characterized, and demonstrated to undergo high yielding Ar-CF3 coupling upon thermolysis. This work provides an attractive conceptual framework for the developement of Pd-II/IV-catalyzed arene trifluoromethylation reactions.

引用

页码：2878 / +

页数：4

共 39 条

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