Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23

被引：7

作者：

Agaba, M

Kemp, SJ

Barendse, W

Teale, AJ

机构：

[1] INT LIVESTOCK RES INST,NAIROBI,KENYA

[2] UNIV LIVERPOOL,DEPT GENET & MICROBIOL,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

[3] UNIV QUEENSLAND,CSIRO,DIV TROP ANIM PROD,MOLEC ANIM GENET CTR,BRISBANE,QLD 4072,AUSTRALIA

来源：

MAMMALIAN GENOME | 1996年 / 7卷 / 03期

关键词：

D O I：

10.1007/s003359900051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified four single-strand conformation variants of the bovine tumor necrosis factor alpha gene by analysis of PCR-amplified fragments. The variants are inherited in Mendelian fashion and are informative for linkage mapping. We have mapped the bovine gene to Chromosome (Chr) 23 in a panel of somatic cell hybrids and observed genetic linkage to the major histocompatibility complex (BoLA) genes and microsatellite markers on bovine Chr 23 in an international bovine reference family panel. The distribution of the alleles was determined in cattle of different breeds and of different geographical origins, which included trypano-susceptible and trypano-tolerant cattle.

引用

页码：186 / 187

页数：2

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