Synthesis of C4-linked imidazole ribonudeoside phosphoramidite with pivaloyloxymethyl (POM) group

被引：22

作者：

Araki, L

Harusawa, S

Yamaguchi, M

Yonezawa, S

Taniguchi, N

Lilley, DMJ

Zhao, ZY

Kurihara, T

机构：

[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

[2] Univ Dundee, Dept Biochem, Dundee DD1 5EH, Scotland

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 12期

关键词：

D O I：

10.1016/j.tetlet.2004.01.132

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel C4-linked imidazole ribonucleoside phosphoramidite was designed and successfully synthesized starting from tribenzylribofuranosylimidazole. This phosphoramidite product enables incorporation of the imidazole moiety into an RNA sequence and hence allows study of its role in the general acid and base catalysis of ribozymes. Pivaloyloxymethyl (POM) was first introduced as an N-protecting group for the imidazole ribonucleoside that can be readily removed under mild basic condition. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2657 / 2661

页数：5

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