Regeneration in insects

被引:18
作者
Marsh, JL [1 ]
Theisen, H
机构
[1] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA
[3] Calif State Univ Fullerton, Dept Sci Biol, Fullerton, CA 92834 USA
关键词
regeneration; pattern formation; gene regulation; morphogen; distalization;
D O I
10.1006/scdb.1999.0323
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In insect limbs, networks of gene regulation mediated by secreted morphogens play hey roles in controlling development, repair and regeneration. Two models for limb patterning and regeneration were proposed in the 1970s: The Polar Coordinate Model and The Boundary Model. Here we describe the molecular networks driving limb development and regeneration and how they support a hybrid PCM-Boundary Model, where circumferential positional values emerge from the interplay of two morphogens with two compartments and distal outgrowth is initiated by the combinatorial signaling of two morphogens, Wingless (Wg) and Decapentaplegic (Dpp). Autoactivating loops and lateral inhibition are prominent mechanisms in these networks.
引用
收藏
页码:365 / 375
页数:11
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