Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation

被引：82

作者：

de Pater, Emma ^{[1
]}

Ciampricotti, Metamia ^{[1
]}

Priller, Florian ^{[2
]}

Veerkamp, Justus ^{[2
]}

Strate, Ina ^{[1
]}

Smith, Kelly ^{[1
]}

Lagendijk, Anne Karine ^{[1
]}

Schilling, Thomas F. ^{[3
]}

Herzog, Wiebke ^{[4
]}

Abdelilah-Seyfried, Salim ^{[2
]}

Hammerschmidt, Matthias ^{[5
]}

Bakkers, Jeroen ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Utrecht, Netherlands

[2] Max Delbruck Ctr Mol Med, Berlin, Germany

[3] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA

[4] Max Planck Inst Mol Biomed, Munster, Germany

[5] Univ Cologne, Bioctr Cologne, Inst Dev Biol, D-50931 Cologne, Germany

来源：

CIRCULATION RESEARCH | 2012年 / 110卷 / 04期

关键词：

BMP; Smad6; Heart; Zebrafish; Bmpr1a; CARDIOMYOCYTE DIFFERENTIATION; HEART DEVELOPMENT; ZEBRAFISH; TBX20; SPECIFICATION; INHIBITION; EXPRESSION; INDUCTION; RECEPTOR; PATTERN;

D O I：

10.1161/CIRCRESAHA.111.261172

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rationale: The importance for Bmp signaling during embryonic stem cell differentiation into myocardial cells has been recognized. The question when and where Bmp signaling in vivo regulates myocardial differentiation has remained largely unanswered. Objective: To identify when and where Bmp signaling regulates cardiogenic differentiation. Methods and Results: Here we have observed that in zebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation into cardiomyocytes. Bmp signaling is continuously required during somitogenesis within the anterior lateral plate mesoderm to induce myocardial differentiation. Surprisingly, Bmp signaling is actively repressed in differentiating myocardial cells. We identified the inhibitory Smad6a, which is expressed in the cardiac tissue, to be required to inhibit Bmp signaling and thereby promote expansion of the ventricular myocardium. Conclusion: Bmp signaling exerts opposing effects on myocardial differentiation in the embryo by promoting as well as inhibiting cardiac growth. (Circ Res. 2012;110:578-587.)

引用

页码：578 / U179

页数：17

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