Antigen-dependent B-cell development

被引：94

作者：

Cariappa, A

Pillai, S ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[2] Harvard Med Sch, Charlestown, MA 02129 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(02)00328-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is growing evidence that the development of naive B cells depends on the interaction of self antigens with the BCR. A view that has emerged over the past year is that BCR signal output contributes in a large part to the developmental fate of peripheral B cells. Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype.

引用

收藏

页码：241 / 249

页数：9

相关论文

共 69 条

[11] PROTEIN-TYROSINE-PHOSPHATASE 1C NEGATIVELY REGULATES ANTIGEN RECEPTOR SIGNALING IN B-LYMPHOCYTES AND DETERMINES THRESHOLDS FOR NEGATIVE SELECTION [J].

CYSTER, JG ;

GOODNOW, CC .

IMMUNITY, 1995, 2 (01) :13-24

[12]

Dammers PM, 1999, EUR J IMMUNOL, V29, P1522, DOI 10.1002/(SICI)1521-4141(199905)29:05<1522::AID-IMMU1522>3.0.CO

[13]

2-0

[14] Most marginal zone B cells in rat express germline encoded Ig VH genes and are ligand selected [J].

Dammers, PM ;

Visser, A ;

Popa, ER ;

Nieuwenhuis, P ;

Kroese, FGM .

JOURNAL OF IMMUNOLOGY, 2000, 165 (11) :6156-6169

[15] Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex [J].

Fearon, DT ;

Carroll, MC .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :393-422

[16] Requirement for NF-κB in osteoclast and B-cell development [J].

Franzoso, G ;

Carlson, L ;

Xing, LP ;

Poljak, L ;

Shores, EW ;

Brown, KD ;

Leonardi, A ;

Tran, T ;

Boyce, BF ;

Siebenlist, U .

GENES & DEVELOPMENT, 1997, 11 (24) :3482-3496

[17] Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration [J].

Fukui, Y ;

Hashimoto, O ;

Sanui, T ;

Oono, T ;

Koga, H ;

Abe, M ;

Inayoshi, A ;

Noda, M ;

Oike, M ;

Shirai, T ;

Sasazuki, T .

NATURE, 2001, 412 (6849) :826-831

[18] Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses [J].

Girkontaite, I ;

Missy, K ;

Sakk, V ;

Harenberg, A ;

Tedford, K ;

Pötzel, T ;

Pfeffer, K ;

Fischer, HD .

NATURE IMMUNOLOGY, 2001, 2 (09) :855-862

[19] Cutting edge: Expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus [J].

Grimaldi, CM ;

Michael, DJ ;

Diamond, B .

JOURNAL OF IMMUNOLOGY, 2001, 167 (04) :1886-1890

[20] The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression [J].

Grossmann, M ;

O'Reilly, LA ;

Gugasyan, R ;

Strasser, A ;

Adams, JM ;

Gerondakis, S .

EMBO JOURNAL, 2000, 19 (23) :6351-6360

← 1 2 3 4 5 6 7 →