Determination of the performance characteristics of a new multi-residue method for non-steroidal anti-inflammatory drugs, corticosteroids and anabolic steroids in food animal tissues

被引:34
作者
Chrusch, J. [1 ]
Lee, S. [1 ]
Fedeniuk, R. [1 ]
Boison, J. O. [1 ]
机构
[1] Ctr Vet Drug Residues, CFIA Saskatoon Lab, CFIA, Saskatoon, SK S7N 2R3, Canada
来源
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2008年 / 25卷 / 12期
关键词
NSAIDs; corticosteroids; anabolic steroids; LC-MS; MS; residues; food animal tissues;
D O I
10.1080/02652030802273122
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A new LC-MS/MS method was developed for the analysis of 29 veterinary drug residues, spanning three different drug classes, in animal tissues. The procedures used to measure the characteristic performance parameters of the method and the results obtained using fortified blank bovine muscle and kidney tissue are described. For a quantitative and confirmatory method, the characteristic performance parameters to be determined are the limits of quantification, trueness, recovery, precision, selectivity, ruggedness, and stability. The characteristic performance parameters defined for the method will be verified during a validation study by an independent experienced analyst to determine whether the method is suitable for use in a regulatory monitoring and control program for residues of the 29 analytes.
引用
收藏
页码:1482 / 1496
页数:15
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