3D-printed microfluidic devices

被引：273

作者：

Amin, Reza ^{[1
]}

Knowlton, Stephanie ^{[2
]}

Hart, Alexander ^{[2
]}

Yenilmez, Bekir ^{[1
]}

Ghaderinezhad, Fariba ^{[1
]}

Katebifar, Sara ^{[2
]}

Messina, Michael ^{[2
]}

Khademhosseini, Ali ^{[3
,4
,5
]}

Tasoglu, Savas ^{[1
,2
]}

机构：

[1] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA

[2] Univ Connecticut, Dept Biomed Engn, Storrs, CT 06269 USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02115 USA

[4] MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

来源：

BIOFABRICATION | 2016年 / 8卷 / 02期

关键词：

3D printing; microfluidics; low-cost fabrication; additive manufacturing; lab-on-a-chip; ON-A-CHIP; ELECTROCHEMICAL DETECTION; FLUIDIC DEVICE; 3D; LAB; STEREOLITHOGRAPHY; REACTIONWARE; GENERATION; ACCURACY; FEATURES;

D O I：

10.1088/1758-5090/8/2/022001

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Microfluidics is a flourishing field, enabling a wide range of biochemical and clinical applications such as cancer screening, micro-physiological system engineering, high-throughput drug testing, and point-of-care diagnostics. However, fabrication of microfluidic devices is often complicated, time consuming, and requires expensive equipment and sophisticated clean room facilities. Three-dimensional (3D) printing presents a promising alternative to traditional techniques such as lithography and PDMS-glass bonding, not only by enabling rapid design iterations in the development stage, but also by reducing the costs associated with institutional infrastructure, equipment installation, maintenance, and physical space. With the recent advancements in 3D printing technologies, highly complex microfluidic devices can be fabricated via single-step, rapid, and cost-effective protocols, making microfluidics more accessible to users. In this review, we discuss a broad range of approaches for the application of 3D printing technology to fabrication of micro-scale lab-on-a-chip devices.

引用

页数：16

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