Telomeres and age-related disease: how telomere biology informs clinical paradigms

被引：312

作者：

Armanios, Mary ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21287 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 03期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; HEMATOPOIETIC STEM-CELLS; DYSKERATOSIS-CONGENITA; REVERSE-TRANSCRIPTASE; APLASTIC-ANEMIA; TERMINAL TRANSFERASE; SECRETORY PHENOTYPE; RNA COMPONENT; RISK-FACTOR; MUTATIONS;

D O I：

10.1172/JCI66370

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.

引用

页码：996 / 1002

页数：7

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