PNA technology

被引：177

作者：

Nielsen, PE ^{[1
]}

机构：

[1] Univ Copenhagen, Panum Inst, Ctr Biomol Recognit, IMBG, DK-2200 Copenhagen, Denmark

来源：

MOLECULAR BIOTECHNOLOGY | 2004年 / 26卷 / 03期

关键词：

peptide nucleic acid; gene targeting; antisense; genetic diagnostics; DNA recognition;

D O I：

10.1385/MB:26:3:233

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine, including drug discovery, genetic diagnostics, molecular recognition, and the origin of life. Recent progress in studies of PNA properties and applications is reviewed.

引用

页码：233 / 248

页数：16

共 136 条

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[34] Substituted 1,8-naphthyridin-2(1H)-ones are superior to thymine in the recognition of adenine in duplex as well as triplex structures
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Nielsen, PE
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[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (09) : 7144 - 7147
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[J]. NATURE BIOTECHNOLOGY, 1998, 16 (04) : 355 - 358
[40] Bactericidal antisense effects of peptide-PNA conjugates
Good, L
Awasthi, SK
Dryselius, R
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[J]. NATURE BIOTECHNOLOGY, 2001, 19 (04) : 360 - 364

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