Tumour microenvironment - Opinion - Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

被引：993

作者：

Overall, CM ^{[1
]}

Kleifeld, O

机构：

[1] Univ British Columbia, Ctr Blood Res, CBCRA Program Breast Canc Metastasis, Dept Oral Biol & Med Sci, Vancouver, BC V6T 1Z3, Canada

[2] Univ British Columbia, Ctr Blood Res, CBCRA Program Breast Canc Metastasis, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

[3] Univ British Columbia, Ctr Blood Res, Life Sci Inst 4 401, Vancouver, BC V6T 1Z3, Canada

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 03期

关键词：

D O I：

10.1038/nrc1821

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The matrix metalloproteinases (MMPs) mediate homeostasis of the extracellular environment. They have multiple signalling activities that are commonly altered during tumorigenesis and that might serve as intervention points for anticancer drugs. However, there are many criteria to consider in validating MMPs as drug targets and for the development of MMP inhibitors. The inhibition of some MMPs could have pro-tumorigenic effects (making them anti-targets), counterbalancing the benefits of target inhibition. These effects might partially account for the failure of MMP inhibitors in clinical trials. What are the major challenges in MMP target validation and MMP-inhibitor-drug development?

引用

页码：227 / 239

页数：13

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