Cancer and the chemokine network

被引：1918

作者：

Balkwill, F ^{[1
]}

机构：

[1] Barts & London, Queen Marys Med Sch, Canc Res UK Translat Oncol Lab, London EC1M 6BQ, England

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrc1388

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A complex network of chemokines and their receptors influences the development of primary tumours and metastases. New information about the biological role of chemokines in these processes is providing insights into host - tumour interactions, such as the role of the leukocyte infiltrate, and into the mechanisms that determine the metastatic potential and site-specific spread of cancer cells. Chemokine-receptor antagonists are showing promise in animal models of inflammation and autoimmune disease. Could manipulating the local chemokine network have therapeutic benefits in malignant disease?

引用

页码：540 / 550

页数：11

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