Adipocyte biology in polycystic ovary syndrome

被引：97

作者：

Barber, T. M. ^{[1
]}

Franks, S. ^{[2
]}

机构：

[1] Univ Warwick, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England

[2] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London W12 0NN, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2013年 / 373卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Polycystic ovary syndrome; Adipocyte; Adipokine; Steroid; Fat distribution; PLASMA ADIPONECTIN CONCENTRATIONS; ADIPOSE-SPECIFIC PROTEIN; REVISED; 2003; CONSENSUS; GROWTH-FACTOR-I; INSULIN-RESISTANCE; METABOLIC SYNDROME; VISCERAL FAT; OBESE WOMEN; 5-ALPHA-REDUCTASE ACTIVITY; DIAGNOSTIC-CRITERIA;

D O I：

10.1016/j.mce.2012.10.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Polycystic Ovary Syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance. There is a clear association between obesity, the development of PCOS and the severity of its phenotypic, biochemical and metabolic features. Evidence to support this link includes data from epidemiological, pathophysiological and genetic studies. Given the importance of obesity in the development and manifestation of PCOS, ongoing research into the many facets of adipocyte biology in women with the condition is important and should continue to be a priority. In this review article, we discuss the existing literature on fat distribution, adipokines, adipocyte hypertrophy and adipocyte steroid metabolism in women with PCOS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：68 / 76

页数：9

共 98 条

[1]

Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary [J].

Agarwal, SK ;

Vogel, K ;

Weitsman, SR ;

Magoffin, DA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (03) :1072-1076

[2]

Obesity and gender influence cortisol secretion and metabolism in man [J].

Andrew, R ;

Phillips, DIW ;

Walker, BR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (05) :1806-1809

[3]

Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome [J].

Apridonidze, T ;

Essah, PA ;

Iuorno, MJ ;

Nestler, JE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (04) :1929-1935

[4]

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[5]

FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome [J].

Attaoua, Redha ;

El Mkadem, Samira Ait ;

Radian, Serban ;

Fica, Simona ;

Hanzu, Felicia ;

Albu, Alice ;

Gheorghiu, Monica ;

Coculescu, Mihai ;

Grigorescu, Florin .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 373 (02) :230-234

[6]

POLYCYSTIC-OVARY-SYNDROME - THE SPECTRUM OF THE DISORDER IN 1741 PATIENTS [J].

BALEN, AH ;

CONWAY, GS ;

KALTSAS, G ;

TECHATRAISAK, K ;

MANNING, PJ ;

WEST, C ;

JACOBS, HS .

HUMAN REPRODUCTION, 1995, 10 (08) :2107-2111

[7]

Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men [J].

Banerji, MA ;

Faridi, N ;

Atluri, R ;

Chaiken, RL ;

Lebovitz, HE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (01) :137-144

[8]

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome [J].

Barber, T. M. ;

Bennett, A. J. ;

Groves, C. J. ;

Sovio, U. ;

Ruokonen, A. ;

Martikainen, H. ;

Pouta, A. ;

Hartikainen, A. -L. ;

Elliott, P. ;

Lindgren, C. M. ;

Freathy, R. M. ;

Koch, K. ;

Ouwehand, W. H. ;

Karpe, F. ;

Conway, G. S. ;

Wass, J. A. H. ;

Jarvelin, M. -R. ;

Franks, S. ;

McCarthy, M. I. .

DIABETOLOGIA, 2008, 51 (07) :1153-1158

[9]

Obesity and polycystic ovary syndrome [J].

Barber, T. M. ;

McCarthy, M. I. ;

Wass, J. A. H. ;

Franks, S. .

CLINICAL ENDOCRINOLOGY, 2006, 65 (02) :137-145

[10]

Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: Associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition [J].

Barber, Thomas M. ;

Hazell, Matthew ;

Christodoulides, Constantinos ;

Golding, Stephen J. ;

Alvey, Christopher ;

Burling, Keith ;

Vidal-Puig, Antonio ;

Groome, Nigel P. ;

Wass, John A. H. ;

Franks, Stephen ;

McCarthy, Mark I. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (07) :2859-2865

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