Derivatives of 3-cyano-6-phenyl-4-(3′-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity

被引：89

作者：

Krauze, A ^{[1
]}

Germane, S ^{[1
]}

Eberlins, O ^{[1
]}

Sturms, I ^{[1
]}

Klusa, V ^{[1
]}

Duburs, G ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 04期

关键词：

1,2-dihydro-2-thioxopyridine-3-carbonitrile; thieno[2,3-b]pyridine; bispyridyldisulfide; antiamnesic agent;

D O I：

10.1016/S0223-5234(99)80081-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione, the related 2,2'-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05-0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg. (C) Elsevier, Paris.

引用

页码：301 / 310

页数：10

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