The role of metabolism in bacterial persistence

被引：171

作者：

Amato, Stephanie M. ^{[1
]}

Fazen, Christopher H. ^{[1
]}

Henry, Theresa C. ^{[2
,3
]}

Mok, Wendy W. K. ^{[1
]}

Orman, Mehmet A. ^{[1
]}

Sandvik, Elizabeth L. ^{[1
]}

Volzing, Katherine G. ^{[1
]}

Brynildsen, Mark P. ^{[1
,2
]}

机构：

[1] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[3] Rutgers State Univ, Rutgers Robert Wood Johnson Med Sch, Piscataway, NJ USA

来源：

FRONTIERS IN MICROBIOLOGY | 2014年 / 5卷

关键词：

bacterial persistence; metabolism; antibiotic tolerance; ppGpp; nutrient environment; MEDIATE ANTIBIOTIC TOLERANCE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; MULTIDRUG TOLERANCE; MYCOBACTERIUM-TUBERCULOSIS; MULTIPLE ANTIBIOTICS; CELLS; STARVATION; GENES; FREQUENCY;

D O I：

10.3389/fmicb.2014.00070

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial persisters are phenotypic variants with extraordinary tolerances toward antibiotics. Persister survival has been attributed to inhibition of essential cell functions during antibiotic stress, followed by reversal of the process and resumption of growth upon removal of the antibiotic. Metabolism plays a critical role in this process, since it participates in the entry, maintenance, and exit from the persister phenotype. Here, we review the experimental evidence that demonstrates the importance of metabolism to persistence, highlight the successes and potential of targeting metabolism in the search for anti-persister therapies, and discuss the current methods and challenges to understand persister physiology.

引用

页数：9

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